"Can't Nobody Hold Me Down" is a hip-hop song by Sean "Puff Daddy" Combs featuring Mase. It appears on Combs' debut album No Way Outand it was released as the first single in 1997.

Combs was already a successful songwriter, producer and record label owner (Bad Boy Records) before he released his debut album as a performer. His first U.S. chart single, "No Time", was a top-twenty hit for Lil' Kim on which Puff Daddy was credited as a featured vocalist. "Can't Nobody Hold Me Down" was the debut chart appearance for Harlem-based rapper Mase.

The song combines elements of several previous singles, the most obvious being a slowed-down rhythm track sampled from Grandmaster Flash and the Furious Five's "The Message". The track's chorus is an interpolation of "Break My Stride", a top-five single by Matthew Wilder from 1983.

"Can't Nobody Hold Me Down" entered the U.S. Billboard Hot 100 at number thirty-two in early 1997 and eventually spent six weeks at number one. It was the beginning of Combs' and Bad Boy Records' chart domination during the year — the Combs-produced "Hypnotize" by The Notorious B.I.G. would follow this song at number one, and the B.I.G. tribute song "I'll Be Missing You" spent eleven weeks at number one during the summer, only to be followed by another B.I.G. song, "Mo Money Mo Problems" and then the Combs-produced "Honey" by Mariah Carey.

The albums from Combs, Mase, B.I.G. and Carey would also dominate the top slots of the Billboard 200 during this time as well.

The packaging for the single stated that the song was from the upcoming album Hell Up in Harlem, retitled as No Way Outprior to its release.