"Crack a Bottle" is a hip hop song by Eminem, Dr. Dre and 50 Cent for Eminem's album Relapse. On February 12, 2009, the song broke the first week digital sales record with 418,000 downloads, topping the previous record held by "Live Your Life" by T.I. featuring Rihanna. This record was broken again the following week by "Right Round" by Flo Rida.The song won the Grammy award for Grammy Award for Best Rap Performance by a Duo or Group at the 52nd Grammy Awards.

"Crack a Bottle" initially gained attention in December 2008, when an unfinished version of the song was initially leaked under the name "Number One" on the mixtape 4th Quarter Pressure Part 2, while a final working version was leaked on January 6, 2009. Various media outlets had reported that the recording was to be the first single from Eminem's 2009 album Relapse, however the Italian branch of Universal Music Group, owner of Interscope Records, later denied this, stating that "Crack a Bottle" was only a promotional recording. Despite all this, the song was released on February 2, 2009, and made available for paid digital download, with 50 Cent stating that the song will be included on his upcoming album Before I Self Destruct. According to Danielle Harling of HipHopDX—a website dedicated to hip hop music coverage—the song will ultimately be present on both Relapseand Before I Self Destruct, while in contrast, Daniel Kreps of Rolling Stonestated that it is still unsure which rapper will feature this song on his upcoming album. Despite the confusion, Universal eventually announced that "Crack a Bottle" will be included in Relapse, although it does not consider it the album's first single.

The song samples "Mais dans la lumière" by Mike Brant, written by Jean Lunard, who also received songwriting credits for the song.

The song is in the key of C-sharp minor.

Billboardgave a positive review of the song: "Although not quite as strong as the title track to Eminem's 2004 album Encore, the return of Eminem, Dr. Dre and 50 Cent has been anticipated for a long time, and it is sure to put Eminem back atop the marquee. His skills remain some of the best in hip-hop, and the accompanying contributions make the music that little bit more stronger." Rolling Stonecommented negatively on the song, saying that it is one of the weakest tracks on the album, along the other single "We Made You". . The song won at the 52nd Grammy Awards in the Grammy Award for Best Rap Performance by a Duo or Group category.

During an interview for MTV, 50 Cent originally told that there were plans to make an animated music video for "Crack a Bottle", which was to be shot along with a music video for his song "I Get It In". On February 25, Eminem's manager Paul Rosenberg posted on his blog a still frame from the music video illustrating a homeless person holding a bottle wrapped in a brown bag. According to Rosenberg, it is directed by Syndrome and was planned to be released within a couple of weeks. The music video was playing on TV in Eminem's music video "3 a.m.", which has been directed by Syndrome too.

On May 7, 2009, an unfinished version of the video was released via TheRelapse.com, featuring Eminem's verse and chorus. Later during the same day, 50 Cent's rapped verse of the video was released via ThisIs50.com as well. This was added to the unfinished video on therelapse.com.

A month later, on June 7, 2009, Cashis posted a link on Twitter to the full video in which he makes a cameo appearance. The music video portrays each rappers' style. Eminem's - chaotic, Dr. Dre - west coast style, 50 Cent's - more club oriented. None of the performers are featured in the video.

Since its release, "Crack a Bottle" has mainly charted in the United States, entering in various charts including the Hot 100 and the Hot R&B/Hip-Hop Songs. The song peaked in top ten on the Hot Rap Tracks, at the number four. After spending three consecutive weeks at number seventy-eight on the Hot 100, on Billboard's edition of February 21, 2009, "Crack a Bottle" reached the number one position on the Hot 100 through sales of 418,000 downloads, thus causing the fourth-biggest jump to the top of the Hot 100 in the chart's history. To date, "Crack a Bottle" is Eminem's second number one song in the U.S. and the first since 2002. With this song, Dr. Dre reached the top of the Hot 100 for a third time, while this is 50 Cent's fourth. The song has also entered in various European national charts, including the Irish Singles Chart and UK Singles Chart, and also debuted at number one on the Canadian Hot 100.