"Me and Mrs. Jones" was written by Kenny Gamble and Leon Huff. It describes an extramarital affair between a man and his lover, Mrs. Jones. It has been recorded by Billy Paul and Michael Bublé, amongst others.

"Me and Mrs. Jones" was a number-one single originally performed by soul singer Billy Paul, recorded and released in 1972 on CBS Records' Epic imprint. The single, included on the album 360 Degrees of Billy Paul, was written by Kenny Gamble and Leon Huff. It describes an extramarital affair between a man and his lover, Mrs. Jones.

The single became Paul's only number-one single on the Billboard Hot 100, peaking at that position for three weeks in December 1972. "Me and Mrs. Jones" also achieved this feat on Billboard's R&B Singles chart, remaining at the number-one position for four weeks. It replaced "I Am Woman" by Helen Reddy and was replaced by Carly Simon's "You're So Vain".

"Me and Mrs. Jones" is the second single to be released off Call Me Irresponsible, Michael Bublé's third album. The song was a collaboration between Bublé's then girlfriend, Emily Blunt appears at the end of the song, singing minor back vocals.

"Me and Mrs. Jones" has been well-received by critics, with Okayplayer even stating

Additionally, the song was promoted by its performance at AOL Sessions. It has additionally been played at many of his concerts promoting his new album.

A music video was made for the song. It consists mainly of Bublé standing in front of a window singing the song. Some scenes show a woman, representing "Mrs. Jones". Some shots from the promotional videos of "Lost" were used (particularly the ones where he lies on a white bed).

Since it is believed that the single was cancelled soon after its release (there was little to no promotion for the song), "Me and Mrs. Jones" was not eligible to chart in any major music charts. However, it did chart in Switzerland.

A cover of the song was also a hit for the 1970s group The Dramatics. Their version peaked at #47 on the pop charts and #4 on the R&B charts in 1974.

It has also been covered by Ten Wedge, Roy Meriwether, Andy Abraham, George Huff, Sandra Bernhard, Head, Sarah Jane Morris, Michael Bublé, Hall & Oates, the experimental rock band Sun City Girls, Amii Stewart and the soul band Tower of Power.

A remake of this song was recorded by Freddie Jackson in 1992. Coolio recorded his own version on his album Gangsta's Paradise, entitled "A Thing Goin' On".

A German version, entitled Sie lässt mich nicht mehr los, was published in 2003 by the German soul singer Stefan Gwildis.

Bobby Brown sampled the song in his first #1 solo hit, "Girlfriend", in 1986.