"Mona Lisa" is an Academy Award-winning song written by Ray Evans and Jay Livingston for the Paramount Pictures film Captain Carey, U.S.A.(1950). The arrangement was by Nelson Riddle and the orchestral backing was played by Les Baxter and his Orchestra. The soundtrack version by Nat King Cole spent eight weeks at number one in the singles chart in 1950. Also, Cole's version of the song was inducted into the Grammy Hall of Fame in 1992. The Billboard sales charts of 1950 also showed significant sales on versions by Dennis Day and Harry James. In 1986, it was used as the theme to the British film Mona Lisa. An uncredited version of Mona Lisaplays in the background of one scene in Alfred Hitchcock's Rear Window(1954). The song was used in the wedding scene of the NBC mini-series, Witness to the Mob, in 1998.

Various artists, including Elvis Presley, Willie Nelson, Art Lund, Shakin' Stevens, Me First and the Gimme Gimmes, and Nat King Cole's daughter Natalie Cole, have released cover versions of this song. Bruddah Iz (Israel Kamakawiwo'ole) also covered the song on the album Alone in IZ World. Harry Connick, Jr. included the song on his 2009 album, Your Songs.

A rockabilly version of "Mona Lisa" (b/w/ "Foolish One") was released by Carl Mann on Phillips International Records (#3539) in March 1959 and reached number 25 on the Billboard Hot 100. Conway Twitty recorded a version of "Mona Lisa" in February 1959 but planned to release it only as an album cut (on an EP and an LP by MGM Records). Sam Phillips signed Carl Mann to record his version of the song after the Twitty version began getting radio play in early 1959. This was the most successful single in Mann's career. The melody is slightly different, and the lyrics are also mostly the same as in the original version by Nat King Cole, though a few more phrases are added in that elaborate more on the girl he likes.

The singer Don Cherry recorded a version backed by the Victor Young Orchestra which reached #7 in 1952.