"Hypnotize" is the Grammy-nominated hip-hop song recorded by Brooklyn rapper The Notorious B.I.G. It was released as the first single from his album Life After Deathin April of 1997.

The song was already a huge hit on U.S. radio stations before its release. Once a single was issued, "Hypnotize" entered the Billboard Hot 100 at number two, right behind labelmate and co-writer/co-producer Puff Daddy ("Can't Nobody Hold Me Down"). When "Hypnotize" hit number one the following week, it made The Notorious B.I.G. the fifth artist in Hot 100 history to have a posthumous chart-topper ( see List of Hot 100 (U.S.) chart achievements and trivia). It also gave back-to-back number-one hits to Sean Combs' Bad Boy Records label. It was nominated for Best Rap Solo Performance at the 1998 Grammy Awards. The single reached #10 in the UK, making this his first top 10 hit in that country.

The rhythm track of "Hypnotize" is based upon a sample of "Rise", a Herb Alpert instrumental, written by Andy Armer and Randy Badazz Alpert, that was a number-one hit in the U.S. in 1979.

The chorus of "Hypnotize", sung by Pamela Long of Total, contains an interpolation of "La Di Da Di" by Doug E. Fresh and Slick Rick.

, The song is featured in the film 10 Things I Hate About Youin a scene where an intoxicated Julia Stiles dances on a table.

The song is also featured in B.I.G.'s biopic Notorious. The song is also the film's theme song as it is played 3 times throughout the film. It was also used in most of the film's advertisements.

The song features many pop culture references to television and film including "Star Wars", "Roots", "Starsky and Hutch", "King of New York" and "Richie Rich" and The Crystals' Da Doo Run Run. As well as references to popular fashion lines "Versace", "DKNY", "Moschino" and "Coogi".